Come see, stay and enjoy the Holiday Inn Express & Suites® Orangeburg Hotel Southern charm, natural beauty, and friendly staff await you at our Orangeburg hotel, located just minutes from Edisto Memorial Gardens. Because of the city's ideal climate and central location, it is known as a hunter's paradise, a golfer's delight, and a nature lover's dream.Business travelers find our hotel's location in Orangeburg, SC a convenient option. Guests can visit a student at South Carolina State, Claflin University, Southern Methodist College and Orangeburg Tech.